Chemistry Department

Department of Chemistry

Queen's University at Kingston

Biophysical and Physical Chemistry/Nuclear Magnetic Resonance

Dr. Gang Wu


Professor of Chemistry

B.Sc.(Peking); M.Sc.(York); Ph.D.(Dalhousie).

Premier's Research Excellence Award, 2000.
Chancellor's Research Award, 2000.
NSERC Postdoctoral Fellowship,
Massachusetts Institute of Technology, 1995-97.
NSERC Doctoral Prize, 1995.

Department of Chemistry
Queen's University
90 Bader Lane
Kingston, Ontario, Canada K7L 3N6
Tel: (613) 533-2644; Fax: (613) 533-6669

Research Interests

Our primary research interests are concerned with the development of nuclear magnetic resonance (NMR) techniques in studying molecular structure, dynamics, and chemical bonding in chemically and biologically important systems. Currently, we are focused on the development and application of NMR in the following major directions: (a) Oxygen-17 NMR as a new probe to study biological solids, (b) Direct detection of alkali metal ions in DNA, and (c) Cation transport through ion channels. 

Selected Recent Publications 

(1)  R. Ida and G. Wu, Direct NMR detection of alkali metal ions bound to G-quadruplex DNA, J. Am. Chem. Soc. 130, 3590-3602 (2008).

(2)  I. C. M. Kwan, A. Wong, Y.-M. She, M. E. Smith, and G. Wu, Direct NMR evidence of Ca2+ ion binding to G-quartets, Chem. Commun. 682-684 (2008). (Featured on the front cover)

(3)  A. Wong, R. Ida, L. Spindler, and G. Wu, Disodium guanosine 5'-monophosphate self-associates into nanoscale cylinders at pH 8: A combined diffusion NMR spectroscopy and dynamic light scattering study, J. Am. Chem. Soc. 127, 6990-6998 (2005).

(4)  G. Wu and A. Wong, Solid-state 23Na NMR determination of the number and coordination of sodium cations bound to Oxytricha nova Telomere Repeat d(G4T4G4), Biochem. Biophys. Res. Commun. 323, 1139-1144 (2004).

(5)  A. Wong and G. Wu, Selective binding of monovalent cations to the stacking G-quartet structure formed by guanosine 5’-monophosphate: A solid-state NMR study, J. Am. Chem. Soc. 125, 13895-13905 (2003). 

(6)  G. Wu, A. Wong, Z. Gan, and J. T. Davis, Direct detection of potassium cations bound to G-quadruplex structures by solid-state 39K NMR at 19.6 T, J. Am. Chem. Soc. 125, 7182-7183 (2003). 

(7)  A. Wong, J. Fettinger, S. L. Forman, J. T. Davis, and G. Wu, The sodium ions inside a lipophilic G-quadruplex as probed by solid-state 23Na NMR, J. Am. Chem. Soc. 124, 742-743 (2002).

(8)  G. Wu, S. Dong, R. Ida and N. Reen, A solid-state 17O nuclear magnetic resonance study of nucleic acid bases, J. Am. Chem. Soc. 124, 1768-1777 (2002).