B.Sc.(Peking); M.Sc.(York); Ph.D.(Dalhousie).
Premier's Research Excellence Award, 2000.
Chancellor's Research Award, 2000.
NSERC Postdoctoral Fellowship,
Massachusetts Institute of Technology, 1995-97.
NSERC Doctoral Prize, 1995.
90 Bader Lane
Ontario, Canada K7L 3N6
|Tel: (613) 533-2644;
Fax: (613) 533-6669|
Our primary research interests are concerned with the development of nuclear magnetic resonance (NMR) techniques in studying molecular structure, dynamics, and chemical bonding in chemically and biologically important systems. Currently, we are focused on the development and application of NMR in the following major directions: (a) Oxygen-17 NMR as a new probe to
study biological solids, (b) Direct detection of alkali metal ions in DNA, and (c) Cation transport through ion
(1) R. Ida and G. Wu, Direct NMR detection of alkali metal ions bound to G-quadruplex DNA, J. Am.
Chem. Soc. 130, 3590-3602 (2008).
(2) I. C. M. Kwan, A. Wong, Y.-M.
She, M. E. Smith, and G. Wu, Direct NMR evidence of Ca2+ ion
binding to G-quartets, Chem. Commun. 682-684 (2008). (Featured on the
(3) A. Wong, R. Ida, L. Spindler, and G. Wu, Disodium guanosine 5'-monophosphate self-associates into nanoscale cylinders at pH 8: A combined diffusion NMR spectroscopy and dynamic light scattering study, J. Am. Chem. Soc. 127, 6990-6998
(4) G. Wu and A. Wong, Solid-state
23Na NMR determination of the number and coordination of sodium cations bound to Oxytricha nova Telomere Repeat
d(G4T4G4), Biochem. Biophys. Res. Commun. 323, 1139-1144
(5) A. Wong and G. Wu, Selective binding of monovalent cations to the stacking G-quartet structure formed by guanosine 5’-monophosphate: A solid-state NMR study, J. Am. Chem. Soc. 125, 13895-13905 (2003).
(6) G. Wu, A. Wong, Z. Gan, and J. T. Davis, Direct detection of potassium cations bound to G-quadruplex structures by solid-state
39K NMR at 19.6 T, J. Am. Chem. Soc. 125, 7182-7183 (2003).
(7) A. Wong, J. Fettinger, S. L. Forman, J. T. Davis, and G. Wu, The sodium ions inside a lipophilic G-quadruplex as probed by solid-state
23Na NMR, J. Am. Chem. Soc. 124, 742-743
(8) G. Wu, S. Dong, R. Ida and N. Reen, A solid-state
17O nuclear magnetic resonance study of nucleic acid bases, J. Am. Chem. Soc. 124, 1768-1777 (2002).