Snieckus Group Research Interests

SNIECKUS GROUP RESEARCH PAGES

THE HOME OF DIRECTED METALATION!

RESEARCH INTERESTS

ASYMMETRIC CATALYSIS

A SERIES OF 3,3'-DI(2-PYRIDYL) BINOLS WAS EASILY PREPARED IN THREE STEPS FROM COMMERCIAL SUBSTANCES USING A

COMBINED DOM-NEGISHI CROSS-COUPLING PROTOCOL (SCHEME 1).

SCHEME 1. RAPID SYNTHESIS OF 3,3'-SUBSTITUTED BINOL DERIVATIVES

THESE COMPOUNDS CONSTITUTE NEW MEMBERS OF THE BINOL LIGAND FAMILY, AND HAVE BEEN SHOWN TO BE AMONG THE MOST

GENERAL, SELECTIVE LIGANDS FOR THE STEREOSELECTIVE ADDITION OF DIETHYLZINC TO BENZALDEHYDES AND CINNAMALDEHYDES

(SCHEME 2, TABLE 1).

SCHEME 1. STEREOSELECTIVE ADDITION OF ET₂ZN TO ALDEHYDES

TABLE 1. RESULTS FOR ET₂ZN ADDITION