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Publications
37. McSorley FR, Wyatt PB,
Martinez A, Delong EF, Hove-Jensen B, Zechel DL: PhnY and PhnZ comprise a new
oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond. J. Am.
Chem. Soc.
2012,
in press online.
36.
He
S-M, Wathier M, Podzelinska K, Wong M, McSorley F, Asfaw, A, Hove-Jensen B, Jia
Z, Zechel DL: Structure and mechanism of PhnP, a phosphodiesterase of the
carbon-phosphorus lyase pathway. Biochemistry, 2011,
50, 8603-15.
35.
Jochimsen B, Lolle S,
McSorely FR, Nabi M, Stougaard J, Zechel DL, Hove-Jensen B: Five phn gene
products as components of a multi-subunit complex of the carbon-phosphorus lyase
pathway for organophosphonate catabolism. Proc Natl Acad Sci USA, 2011,
108, 11393-8.
34.
Härle J,
Günther S, Lauinger B, Weber M, Kammerer B, Zechel DL, Luzhetskyy A, Bechthold
A: Rational design of an aryl-C-glycoside catalyst from a natural product
O-glycosyltransferase. Chem Biol 2011, 18, 520-30.
33. Hove-Jensen B, McSorely
F, Zechel DL:
Physiological role of phnP-specified phosphoribosyl cyclic
phosphodiesterase in catabolism of organophosphonic acids by the
carbon-phosphorus lyase pathway. J. Am. Chem. Soc. 2011,
133, 3617-24.
32.
Groom K,
Bhattacharya A, Zechel DL: Rebeccamycin
and staurosporine biosynthesis: Insight into the mechanisms of the
flavin-dependent monooxygenases RebC and StaC.
ChemBioChem
2011,
12, 396-400.
31.
Podzelinska K, Latimer R, Bhattacharya A, Vining LC, Zechel DL, Jia Z:
The structure of CmlS, a flavin-dependent
halogenase involved in the biosynthesis of chloramphenicol.
J. Mol. Biol.
2010,
397,
316-331.
30.
Hove-Jensen B, Rosenkrantz TJ, Zechel DL, Willemoes M:
Accumulation of intermediates of the
carbon-phosphorus lyase pathway for phosphonate degradation in phn
mutants of Escherichia coli.
J. Bacteriol. 2010,
192,
370-374.
29. Nelson GW, Perry M, He
SM, Zechel DL, Horton JH:
Characterization of covalently bonded proteins
on poly(methyl methacrylate) by X-ray photoelectron spectroscopy.
Colloids. Surf. B Biointerfaces
2010,
78,
61-68.
28.
Suits MDL, Zhu Y, Taylor EJ, Walton J, Zechel DL, Gilbert HJ, Davies GJ:
Structure and kinetic investigation of
Streptococcus pyogenes family GH38
a-mannosidase.
PLoS ONE
2010,
5,
e9006.
27. Tailford LE,
Ducros VM, Flint JE, Roberts SM, Morland C, Zechel DL, Smith N, Bjornvad ME,
Borchert TV, Wilson KS, Davies GJ*, Gilbert HJ:
Understanding how diverse
b-mannanases
recognize heterogeneous substrates.
Biochemistry 2009,
48,
7009-7018.
26. Podzelinska
K, He SM, Wathier M, Yakunin A, Proudfoot M, Hove-Jensen B, Zechel
DL, Jia Z: Structure of PhnP, a
phosphodiesterase of the carbon-phosphorus lyase pathway for phosphonate
degradation. J. Biol. Chem.
2009,
284,
17216-17226.
25. Offen WA,
Zechel DL, Withers SG, Gilbert HJ, Davies GJ:
Structure of the Michaelis complex of
b-mannosidase,
Man2A, provides insight into the conformational itinerary of mannoside
hydrolysis. Chem. Commun. (Camb)
2009,
2484-2486.
24. Latimer R,
Podzelinska K, Soares A, Bhattacharya A, Vining LC, Jia Z, Zechel DL:
Expression, purification and preliminary
diffraction studies of CmlS. Acta.
Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
2009,
65,
260-263.
23. He
SM, Luo Y, Hove-Jensen B, Zechel DL:
A fluorescent substrate for carbon-phosphorus
lyase: towards the pathway for organophosphonate metabolism in bacteria.
Bioorg. Med. Chem. Lett.
2009,
19,
5954-5957.
22. Podzelinska
K, He S, Soares A, Zechel DL, Hove-Jensen B, Jia Z:
Expression, purification and preliminary
diffraction studies of PhnP. Acta.
Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
2008,
64,
554-557.
21. Adams MA,
Luo Y, Hove-Jensen B, He SM, van Staalduinen LM, Zechel DL, Jia Z:
Crystal structure of PhnH: an essential
component of carbon-phosphorus lyase in Escherichia coli.
J. Bacteriol.
2008,
190,
1072-1083.
20. van
Staalduinen LM, Bhattacharya A, Groom K, Zechel DL, Jia Z:
Expression, purification and preliminary X-ray
diffraction studies of RebC. Acta.
Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
2007,
63,
980-982.
19. Gloster TM,
Meloncelli P, Stick RV, Zechel DL, Vasella A, Davies GJ:
Glycosidase inhibition: an assessment of the
binding of 18 putative transition-state mimics.
J. Am. Chem. Soc.
2007,
129,
2345-2354.
18. Luo
Y, Zechel DL: A concise synthesis of
a-D-ribofuranosyl
alkylphosphonates: putative substrate intermediates for the carbon phosphorous
lyase system. Can. J. Chem.
2006,
84,
743-747.
17. Matsuura T,
Ernst A, Zechel DL, Pluckthun A:
Combinatorial approaches to novel proteins.
ChemBioChem
2004,
5,
177-182.
16. Zechel DL,
Reid SP, Stoll D, Nashiru O, Warren RA, Withers SG:
Mechanism, mutagenesis, and chemical rescue of
a b-mannosidase
from Cellulomonas fimi.
Biochemistry 2003,
42,
7195-7204.
15. Zechel DL,
Boraston AB, Gloster T, Boraston CM, Macdonald JM, Tilbrook DM, Stick RV, Davies
GJ: Iminosugar glycosidase inhibitors:
structural and thermodynamic dissection of the binding of isofagomine and
1-deoxynojirimycin to b-glucosidases.
J. Am. Chem. Soc.
2003,
125,
14313-14323.
14. Varrot A,
Tarling CA, Macdonald JM, Stick RV, Zechel DL, Withers SG, Davies GJ:
Direct observation of the protonation state of
an imino sugar glycosidase inhibitor upon binding.
J. Am. Chem. Soc.
2003,
125,
7496-7497.
13. Ducros VM,
Tarling CA, Zechel DL, Brzozowski AM, Frandsen TP, von Ossowski I, Schulein M,
Withers SG, Davies GJ: Anatomy of
glycosynthesis: structure and kinetics of the Humicola insolens Cel7B
E197A and E197S glycosynthase mutants.
Chem. Biol.
2003,
10,
619-628.
12. Davies GJ,
Ducros VM, Varrot A, Zechel DL: Mapping
the conformational itinerary of b-glycosidases
by X-ray crystallography. Biochem.
Soc. Trans. 2003,
31,
523-527.
11. Ducros VM,
Zechel DL, Murshudov GN, Gilbert HJ, Szabo L, Stoll D, Withers SG, Davies GJ:
Substrate distortion by a
b-mannanase:
snapshots of the Michaelis and covalent-intermediate complexes suggest a B2,5
conformation for the transition state.
Angew. Chem. Int. Ed. Engl.
2002,
41,
2824-2827.
10. Zechel DL,
Withers SG: Dissection of nucleophilic
and acid-base catalysis in glycosidases.
Curr. Opin. Chem. Biol.
2001,
5,
643-649.
9. Zechel DL,
Reid SP, Nashiru O, Mayer C, Stoll D, Jakeman DL, Warren RA, Withers SG:
Enzymatic synthesis of carbon-fluorine bonds.
J. Am. Chem. Soc.
2001,
123,
4350-4351.
8. Nashiru O,
Zechel DL, Stoll D, Mohammadzadeh T, Warren RA, Withers SG:
b-Mannosynthase:
synthesis of b-mannosides
with a mutant b-mannosidase.
Angew. Chem. Int. Ed. Engl.
2001,
40,
417-420.
7. Zechel DL,
Withers SG: Glycosidase mechanisms:
anatomy of a finely tuned catalyst.
Acc. Chem. Res. 2000,
33,
11-18.
6. Mayer C,
Zechel DL, Reid SP, Warren RA, Withers SG:
The E358S mutant of Agrobacterium sp.
b-glucosidase
is a greatly improved glycosynthase.
FEBS Lett. 2000,
466,
40-44.
5. Zechel DL, Withers SG:
Glycosyl Transferase
Mechanisms.
In
Comprehensive Natural Products Chemistry. Edited by Poulter CD: Elsevier;
1999, vol 5, pp. 279-314.
4. Zechel DL,
Konermann L, Withers SG, Douglas DJ:
Pre-steady state kinetic analysis of an enzymatic reaction monitored by
time-resolved electrospray ionization mass spectrometry.
Biochemistry
1998,
37,
7664-7669.
3. Zechel DL, He
S, Dupont C, Withers SG: Identification
of Glu-120 as the catalytic nucleophile in Streptomyces lividans
endoglucanase celB. Biochem. J.
1998,
336,
139-145.
2. D.L. Zechel, K.C. Hultzsch,
R. Rulkens, D. Balaishis, Y. Ni, J.K. Pudelski, A.J. Lough, I. Manners, D.A.
Foucher. Thermal and transition-metal-catalyzed ring-opening polymerization (ROP)
of [1]silaferrocenophanes with chlorine substituents at silicon: A route to
tunable poly(ferrocenylsilanes). Organometallics 1996, 15,
1972-1978.
1. D.L. Zechel, D.A. Foucher,
J.K. Pudelski, G.P.A. Yap, A.L. Rheingold, I. Manners. Synthesis, structural
characterization, electrochemical properties and polymerization behaviour of the
first silicon-bridged [1.1]ferrocenophane [{Fe(h-C5H4)2SiMe2}2].
J. Chem. Soc., Dalton Trans. 1995, 1893-1899.
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