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Research collaborations

 The MS facility continues its ongoing efforts to support some critical research projects and highlights these application areas of MS strength. A collaborative network for analyzing biomolecules with many research scientists has been established. The joint team effort between the MS facility members and the following researcher groups has been creating new collaborative opportunities for a large number of research projects. The MS facility provides its unique expertise, instrumentation and technical strategies in helping the research groups to establish excellent co-operation programs especially in the cutting-edge research area of protein chemistry, chemical biology, structural biology and proteomics. 

 Participating scientists and research groups

Dr. Gang Wu (Department of Chemistry, Queen’s University)
Dr. Zongchao Jia (Department of Biochemistry, Queen’s University)
Dr. Susan Cole (Department of Pharmacology & Toxicology, Queen’s University)
Dr. William C. Plaxton (Department. of Biology, Queen’s University)
Dr. Ceredwyn E Hill (Department of Medicine & Physiology, Queen’s University)
Dr. Xiaolong Yang (Department of Pathology and Molecular Medicine, Queen’s University)
Dr. Victor Tron (Department of Pathology and Molecular Medicine, Queen’s University)
 Dr. Harry Schachter (Molecular Structure & Function, Hospital for Sick Children)
Dr. Aled Edwards (Structural Genomics Consortium, University of Toronto)
Dr. Sirano Dhe-Paganon (Structural Genomics Consortium, University of Toronto)
Dr. Alexander F. Yakunin (Structural Proteomics in Toronto, University of Toronto)
Dr. Kenneth G. Standing (Department of Physics, University of Manitoba)
Dr. Frank Burczynski (Department of Pharmacy, University of Manitoba)
Dr. Andrew M Kropinski (Laboratory for Foodborne Zoonoses, Public Health Agency of Canada)

 Research highlights

 

 

 Publications from the MS facility members (2007-2008) 

  1. Lee DC, Zheng J, She YM, Jia Z. Structure of Escherichia Coli tyrosine kinase EtK reveals novel activation mechanism. EMBO J. 2008, 27(12), 1758-1766. 
  2. Uhrig RG, She YM, Leach CA, Plaxton WW. Regulatory monoubiquitination of phosphoenolpyruvate carboxylase in germinating castor oil seeds. J. Biol. Chem. 2008, 283(44):29650-29657.
  3. Uhrig RG, O’leary B, Spang HE, MacDonald JA, She YM, Plaxton WC.  Co-immunopurification of phosphorylated bacterial- and plant-type phosphoenol-pyruvate carboxylases with the plastidial pyruvate dehydrogenase complex from developing castor oil seeds. Plant Physiol, 2008, 146 (3) 1346-1357.
  4. Lingohr EJ, Vilegas A, She YM, Ceyssens PJ, Kropinski AM. The genome and proteome of the Kluyvera bacteriophage Kvp1 – another member of the T7-like Autographivirinae. Virol. J. 2008, 5:122.
  5. Mendez II, Weiner SG. She YM, Yeager M, Coombs KM. Conformation changes accompany activation of reovirus RNA-dependent RNA polymerase. Journal of Structural Biology. 2008, 162(2), 277-289.  
  6. Kwan ICM, Wong A, She YM, Smith ME, Wu G. Direct NMR evidence for Ca2+ ion binding to G-quartets. Chem Commun, 2008, 6, 682-684
  7. Keller BO, Sui J, Young AB, Whittal RM. Interferences and contaminants encountered in modern mass spectrometry. Anal. Chim. Acta 2008, 627, 71-81
  8. Wang PYT, Boccanfuso M, Lemay AM, Devries H, Sui J, She YM. Hill CE. Sex-specific extraction of organic anions by the rat liver. Life Sci. 2008, 82(7-8), 436-443.
  9. She YM, Krokhin O, Spicer V, Loboda A, Garland G, Ens W, Standing KG. Formation of (bn-1 + H2O) ions by collisional activation of MALDI-formed peptide [M+H]+ ions in a QqTOF mass spectrometer. J. Am. Soc. Mass Spectrom. 2007, 18(6), 1024-1037.
  10. Smith CA, Lau KM, Rahmani Z, Dho SE, Brothers G, She YM, Berry DM, Bonneil E, Thibault P, Schweisguth F, Le Borgne R, McGlade CJ. aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb. EMBO J. 2007, 26(2), 468-480.
  11. Narindrasorasak S, Kulkarni P, Deschamps P, She YM, Sarkar B. Characterization and copper binding properties of human COMMD1 (MURR 1). Biochemistry, 2007, 46(11), 3116-3128.
  12. Kwan ICM, She YM, Wu G. Trivalent lanthanide metal ions promote formation of stacking G-quartets. Chemical Communications, 2007, 41, 4286-4288.
  13. Weerasekera R, She YM, Markham K, Bai Y, Opalka N, Orlicky S. Sicheri F. Kislinger T, Schmitt-Ulms G. Interactome and interface protocol (2IP): a novel strategy for high sensitivity topology mapping of protein complexes. Proteomics, 2007, 7(21), 3835-3852.
  14. Crandall IE, Szarek WA, Vlahakis JZ, Xu Y, Vohra R, Sui J, Kisilevsky R. Sulfated cyclodextrins inhibit the entry of plasmodium into red blood cells: implications for malarial therapy. Biochem Pharmacology, 2007, 73(5): 632-642.