Homonuclear 3D experiments

Homonuclear 3D experiments involve only one type of nuclei (for example : Proton).
It consists of correlating the various nuclei either through scalar coupling (COSY, TOCSY) or through space (NOESY)
by combining two 2D experiments.

Experiments in that category are for example :

3D structure

All 3D experiments consists of the following structure:
 
preparation 
first evolution
t1
First Mixing
Mix1
second evolution
t2
Second Mixing
Mix2
Detection
t3
The spectra is then Fourier Transform along the 3 time domain axis. This will provide a spectra that looks like a cube with the 3 frequency axis (F1, F2 and F3) running along the edges.

Spectra analysis

To help your understanding of homonuclear 3D NMR experiment you can view the
animation showing 3D-NOESY-TOCSY 



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